Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.

@article{Cavarra1999NeutrophilII,
  title={Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.},
  author={Eleonora Cavarra and Piero Antonio Martorana and Maria Margherita de Santi and Barbara Bartalesi and Stefania Cortese and Federica Gambelli and Giuseppe Lungarella},
  journal={American journal of respiratory cell and molecular biology},
  year={1999},
  volume={20 2},
  pages={264-9}
}
The beige mouse is currently used as a model of elastase and cathepsin G deficiency to demonstrate or exclude the role of these proteases in a variety of pathologic conditions. We recently demonstrated that beige cathepsin G is tightly bound to neutrophil lysosomal membranes but is released in near normal quantities during exocytosis. Also, beige… CONTINUE READING