Neutrophil hyperchemotaxis in Behçet’s disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses

@article{Neves2009NeutrophilHI,
  title={Neutrophil hyperchemotaxis in Behçet’s disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses},
  author={Fabr{\'i}cio de Souza Neves and Solange Carrasco and Cl{\'a}udia Goldenstein-Schainberg and C{\'e}lio Roberto Gonçalves and Suzana Beatriz Ver{\'i}ssimo de Mello},
  journal={Clinical Rheumatology},
  year={2009},
  volume={28},
  pages={1403-1410}
}
Increased neutrophil chemotaxis and hyperresponsiveness to streptococci have been considered to play a role in Behçet’s disease (BD) pathogenesis. Our aim was to correlate TLR2 expression and chemotactic responses stimulated by bacterial lipoteichoic acid (LTA) in BD neutrophils. Thus, we assessed expressions of TLR2 and the correlate receptors CD14, CD114 (G-CSF receptor), CD116 (GM-CSF receptor) and also TLR4 on circulating neutrophils and monocytes of patients with active BD. Serum… CONTINUE READING
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