Neutrophil hyperactivation correlates with Alzheimer's disease progression

@article{Dong2018NeutrophilHC,
  title={Neutrophil hyperactivation correlates with Alzheimer's disease progression},
  author={Yuan Dong and Julien Lagarde and Laura Xicota and H. W. Klaassen Corn{\'e} and Yannick Chantran and Thomas Chaigneau and Bruno Crestani and Michel Bottlaender and Marie-Claude Potier and P. Aucouturier and Guillaume Doroth{\'e}e and Marie Sarazin and Carole Elbim},
  journal={Annals of Neurology},
  year={2018},
  volume={83},
  pages={387–405}
}
OBJECTIVE Recent studies have underlined the effect of systemic inflammation on the pathophysiology of Alzheimer's disease (AD). Neutrophils are key components of early innate immunity and contribute to uncontrolled systemic inflammation if not tightly regulated. The aim of our study was to fully characterize human circulating neutrophils at different disease stages in AD. METHODS We analyzed neutrophil phenotypes and functions in 42 patients with AD (16 with mild cognitive impairment and 26… CONTINUE READING
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