Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor.

@article{Laskay2008NeutrophilGA,
  title={Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor.},
  author={Tam{\'a}s Laskay and Ger van Zandbergen and W Solbach},
  journal={Immunobiology},
  year={2008},
  volume={213 3-4},
  pages={183-91}
}
Polymorphonuclear neutrophil granulocytes (PMN) are primary antimicrobial effector cells of the innate immune system and serve to destroy invading pathogens. Although most ingested microorganisms are killed readily inside PMN, several obligate or facultative intracellular pathogens survive even in this hostile environment. Extension of the life span of neutrophils is a general escape mechanism of pathogens residing in PMN. However, after 2-4 days, even infected neutrophils become apoptotic and… CONTINUE READING

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