Neutrophil granule contents in the pathogenesis of lung injury

@article{Moraes2006NeutrophilGC,
  title={Neutrophil granule contents in the pathogenesis of lung injury},
  author={Theo J Moraes and Joanna H. Zurawska and Gregory P. Downey},
  journal={Current Opinion in Hematology},
  year={2006},
  volume={13},
  pages={21–27}
}
Purpose of reviewThis review summarizes recent literature on the role of neutrophil granule contents in acute lung injury and the mechanisms by which these contribute to inflammatory tissue injury. Recent findingsNeutrophil products such as elastase, reactive oxygen species, and antimicrobial peptides can alter pulmonary cell function in a nondegradative fashion through activation of cell surface receptors or modulation of signal transduction pathways. These effects can be either beneficial or… Expand
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