Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis

@inproceedings{BellmannWeiler2013NeutrophilGL,
  title={Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis},
  author={Rosa Bellmann-Weiler and Andrea Schroll and Sabine Engl and Manfred Nairz and Heribert Talasz and Markus Seifert and Guenter Weiss},
  booktitle={Immunobiology},
  year={2013}
}
Neutrophil gelatinase-associated lipocalin (NGAL/Lipocalin-2/Lcn-2) is a 25kDa protein which is involved in host defence against certain Gram negative bacteria upon binding of iron loaded bacterial siderophores thereby limiting the availability of this essential nutrient to bacteria resulting in inhibition of their growth and pathogenicity. As iron is important for the growth of the intracellular bacterium Chlamydia pneumoniae we questioned whether Lcn-2 affects the course of this infection. We… CONTINUE READING

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