Neutrophil fate in experimental glomerular capillary injury in the rat. Emigration exceeds in situ clearance by apoptosis.

@article{Hughes1997NeutrophilFI,
  title={Neutrophil fate in experimental glomerular capillary injury in the rat. Emigration exceeds in situ clearance by apoptosis.},
  author={J. E. Hughes and Richard J Johnson and Andrew Mooney and Christian P. M. Hugo and Kereen B Gordon and John Savill},
  journal={The American journal of pathology},
  year={1997},
  volume={150 1},
  pages={223-34}
}
Neutrophils (PMNs) and their toxic contents can injure glomeruli, but to date their fate in glomerulonephritis has been unknown. We studied glomerulonephritis induced in rats by formation of concanavalin A (Con A)/anti-Con A immune complexes on glomerular endothelial cells. PMN infiltration, which was almost exclusively confined to the lumen of glomerular capillaries, was transient, peaking at 4 hours, with only 9.0 +/- 4.1% (mean +/- SEM) of the maximum remaining at 24 hours. There was clear… CONTINUE READING
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