Neutrophil extracellular traps - the dark side of neutrophils.

  title={Neutrophil extracellular traps - the dark side of neutrophils.},
  author={Ole E S\orensen and Niels Borregaard},
  journal={The Journal of clinical investigation},
  volume={126 5},
Neutrophil extracellular traps (NETs) were discovered as extracellular strands of decondensed DNA in complex with histones and granule proteins, which were expelled from dying neutrophils to ensnare and kill microbes. NETs are formed during infection in vivo by mechanisms different from those originally described in vitro. Citrullination of histones by peptidyl arginine deiminase 4 (PAD4) is central for NET formation in vivo. NETs may spur formation of autoantibodies and may also serve as… CONTINUE READING
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