Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

@article{Warnatsch2015NeutrophilET,
  title={Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis},
  author={Annika Warnatsch and Marianna Ioannou and Qian Wang and Venizelos Papayannopoulos},
  journal={Science},
  year={2015},
  volume={349},
  pages={316-320}
}
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of immature IL-1β, and then endogenous “danger” signals activate innate immune signaling complexes called inflammasomes to process IL-1β for secretion. Although cholesterol crystals are known to act as danger signals in atherosclerosis, what primes IL-1β transcription remains elusive. Using a murine model of atherosclerosis… CONTINUE READING
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