Neutrophil extracellular traps are associated with inflammation in chronic airway disease.

  title={Neutrophil extracellular traps are associated with inflammation in chronic airway disease.},
  author={Thomas K. Wright and Peter G Gibson and Jodie L Simpson and Vanessa M McDonald and Lisa G Wood and Katherine Joanne Baines},
  volume={21 3},
BACKGROUND AND OBJECTIVE Neutrophil extracellular traps (NETs) are web-like structures comprising DNA and antimicrobial proteins, expelled from neutrophils during NETosis. Persistence of NETs can be pro-inflammatory, yet their role in respiratory disease remains unclear. This study aimed to investigate the presence of NETs in sputum from patients with asthma and COPD, and the relationship of NETs with inflammatory phenotype and disease severity. METHODS Induced sputum was collected from… CONTINUE READING
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