Neutrophil extracellular trap release driven by bacterial motility: Relevance to cystic fibrosis lung disease

@inproceedings{Rada2017NeutrophilET,
  title={Neutrophil extracellular trap release driven by bacterial motility: Relevance to cystic fibrosis lung disease},
  author={Bal{\'a}zs Rada},
  booktitle={Communicative & integrative biology},
  year={2017}
}
Neutrophil extracellular trap (NET) formation represents a unique effector function of neutrophils (PMN). The mechanism of NET release in response to bacteria is largely unknown. We studied the process by which Pseudomonas aeruginosa, an opportunistic pathogen, interacts with primary PMNs, and found that flagellar swimming motility of the bacterium is essential for inducing NET extrusion. Cystic fibrosis (CF) lung disease is associated with P. aeruginosa infection and PMN-dominated inflammation… CONTINUE READING
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