Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.

@article{Smith2014NeutrophilET,
  title={Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.},
  author={Carolyne K Smith and Anuradha Vivekanandan-Giri and Chongren Tang and Jason S. Knight and Anna Vachaparampil Mathew and Robin L Padilla and Brenda W. Gillespie and Carmelo Carmona-Rivera and Xiaodan Liu and Venkataraman Subramanian and Sarfaraz Hasni and Paul R Thompson and Jay W. Heinecke and Rajiv Saran and Subramaniam Pennathur and Mariana J Kaplan},
  journal={Arthritis & rheumatology},
  year={2014},
  volume={66 9},
  pages={2532-2544}
}
OBJECTIVE Oxidative stress and oxidized high-density lipoprotein (HDL) are implicated as risk factors for cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). Yet, how HDL is oxidized and rendered dysfunctional in SLE remains unclear. Neutrophil extracellular traps (NETs), the levels of which are elevated in lupus, possess oxidant-generating enzymes, including myeloperoxidase (MPO), NADPH oxidase (NOX), and nitric oxide synthase (NOS). We hypothesized that NETs mediate HDL… CONTINUE READING
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