Neutrophil-endothelial cell interactions during the development of tolerance to ischaemia/reperfusion in isolated cells.

@article{Cepinskas2001NeutrophilendothelialCI,
  title={Neutrophil-endothelial cell interactions during the development of tolerance to ischaemia/reperfusion in isolated cells.},
  author={Gediminas Cepinskas and Tao Rui and Peter R. Kvietys},
  journal={Acta physiologica Scandinavica},
  year={2001},
  volume={173 1},
  pages={23-33}
}
Ischaemia/reperfusion (I/R) tolerance refers to the phenomenon by which the inflammation and associated sequelae induced by I/R is ameliorated by an I/R challenge imposed 24 h earlier. The development of I/R tolerance is dependent on the synthesis of new proteins. In vivo and in vitro studies provide support for nitric oxide synthase (NOS), antioxidant enzymes, and heat shock proteins (HSPs) as the effector proteins. Activation of the nuclear transcription factor, NFkappaB, appears to be a… CONTINUE READING