Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis.

@article{Ouriaghli2003NeutrophilEE,
  title={Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis.},
  author={Frank El Ouriaghli and Hiroshi Fujiwara and J. Joseph Melenhorst and Giuseppe Sconocchia and Nancy Fern Hensel and Austin John Barrett},
  journal={Blood},
  year={2003},
  volume={101 5},
  pages={
          1752-8
        }
}
There is evidence that neutrophil production is a balance between the proliferative action of granulocyte-colony-stimulating factor (G-CSF) and a negative feedback from mature neutrophils (the chalone). Two neutrophil serine proteases have been implicated in granulopoietic regulation: pro-proteinase 3 inhibits granulocyte macrophage-colony-forming unit (CFU-GM) growth, and elastase mutations cause cyclic and congenital neutropenia. We further studied the action of the neutrophil serine… CONTINUE READING

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