Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation

@inproceedings{Piper2009NeutrophilED,
  title={Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation},
  author={Melissa G. Piper and Pam R Massullo and Megan J. Loveland and Lawrence J. Druhan and Tamila L. Kindwall-Keller and Jing Ai and Alexander Copelan and Belinda R. Avalos},
  booktitle={Journal of Inflammation},
  year={2009}
}
The granulocyte colony-stimulating factor receptor (G-CSFR) plays a critical role in maintaining homeostatic levels of circulating neutrophils (PMN). The mechanisms modulating G-CSFR surface expression to prevent chronic neutrophilia are poorly understood. Here, we report that neutrophil elastase (NE) proteolytically cleaves the G-CSFR on human PMN and blocks G-CSFR-mediated granulopoiesis in vitro. Human peripheral blood PMN isolated from healthy donors were incubated with NE. Expression of… CONTINUE READING

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Proteases produced by activated neutrophils are able to release soluble CD23 fragments endowed with proinflammatory effects.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2001
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