Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo.

Abstract

Neutrophil elastase (NE) remains a controversial player in the process of leukocyte transmigration and much of this controversy stems from conflicting reports on the effects of NE inhibitors. The availability of NE-deficient mice (NE(-/-)) provides a clean and elegant tool for the study of leukocyte migration in vivo. In this study, NE(-/-) mice were used… (More)

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Cite this paper

@article{Young2004NeutrophilE, title={Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo.}, author={Rebecca E. Young and Richard Damian Thompson and Karen Y. Larbi and Mylinh La and Clare E. Roberts and Steven D Shapiro and Mauro Perretti and Sussan Nourshargh}, journal={Journal of immunology}, year={2004}, volume={172 7}, pages={4493-502} }