Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation.

@article{Solomkin1981NeutrophilDI,
  title={Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation.},
  author={Joseph S. Solomkin and Marc K Jenkins and R. David Nelson and D E Chenoweth and Richard L. Simmons},
  journal={Surgery},
  year={1981},
  volume={90 2},
  pages={319-27}
}
Abnormalities in chemotactic and bactericidal activity have been identified in patients suffering from burn injury, trauma, and infection. Such abnormalities may lead to bacteremia or nosocomial infection. The mechanism for these abnormalities is unclear. We studied the role of chemotactic deactivation by complement component C5a in 47 patients with intra-abdominal infection and with disordered neutrophil function. Plasma C5a levels in such patients were elevated (102.1 +/- 8.3 versus 52.6… CONTINUE READING

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