Neutrophil deactivation by influenza A virus. Role of hemagglutinin binding to specific sialic acid-bearing cellular proteins.

@article{Hartshorn1995NeutrophilDB,
  title={Neutrophil deactivation by influenza A virus. Role of hemagglutinin binding to specific sialic acid-bearing cellular proteins.},
  author={Kevan L Hartshorn and Louis S. Liou and Mitchell R. White and Michael M. Kazhdan and Jan Tauber and Alfred I. Tauber},
  journal={Journal of immunology},
  year={1995},
  volume={154 8},
  pages={3952-60}
}
Bacterial superinfections are the most common cause of mortality during influenza epidemics. Depression of phagocyte functions by influenza A viruses (IAVs) is a likely contributory cause of such infections. We used an in vitro model of viral depression of neutrophil respiratory burst responses to FMLP and PMA to examine the mechanism of IAV-induced phagocyte deactivation. Respiratory burst responses or intracellular calcium mobilization were triggered by the virus itself, but these were not… CONTINUE READING

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We used an in vitro model of viral depression of neutrophil respiratory burst responses to FMLP and PMA to examine the mechanism of IAV - induced phagocyte deactivation .
We used an in vitro model of viral depression of neutrophil respiratory burst responses to FMLP and PMA to examine the mechanism of IAV - induced phagocyte deactivation .
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