Neutrophil clearance: when the party is over, clean-up begins.

@article{Bratton2011NeutrophilCW,
  title={Neutrophil clearance: when the party is over, clean-up begins.},
  author={Donna L. Bratton and Peter M Henson},
  journal={Trends in immunology},
  year={2011},
  volume={32 8},
  pages={350-7}
}
Maintenance of circulating, functional neutrophils and their robust recruitment to tissues in response to injury and/or microbial infection are crucial for host defense. Equally important, although less well understood, are the processes for removal of these short-lived cells. Here, we review recent findings of novel neutrophil characteristics that determine removal. These neutrophil-derived signals, in turn, can shape the responses of other cells and surrounding tissues and promote a return to… CONTINUE READING