• Biology, Medicine
  • Published in Journal of immunology 1987

Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).

@article{Yoshimura1987NeutrophilCF,
  title={Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).},
  author={Teizo Yoshimura and Kouji Matsushima and Joost J Oppenheim and Edward J. Leonard},
  journal={Journal of immunology},
  year={1987},
  volume={139 3},
  pages={
          788-93
        }
}
LPS stimulated human blood mononuclear leukocytes to produce a chemotactic factor for human neutrophils. The effect of LPS was dose-dependent; 10 micrograms/ml was optimal for production of chemotactic factor. Chemotactic activity was detected 3 hr after LPS stimulation, and reached its peak at 12 hr. No activity was detected in culture supernatants of unstimulated cells, provided LPS-free media were selected. Isoelectric point of the factor, determined by chromatofocusing, was approximately 8… CONTINUE READING

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