Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma.

@article{Pham2017NeutrophilAA,
  title={Neutrophil autophagy and extracellular DNA traps contribute to airway inflammation in severe asthma.},
  author={Duy Le Pham and G-Y Ban and Seung-Hyun Kim and Yoo Seob Shin and Y-M Ye and Y-J Chwae and Hyungbin Park},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2017},
  volume={47 1},
  pages={57-70}
}
BACKGROUND Autophagy and neutrophil extracellular DNA traps (NETs) are implicated in asthma; however, their roles in asthma pathogenesis have not been elucidated. OBJECTIVES We compared autophagy and NET production levels from peripheral blood neutrophils (PBNs) of patients with severe asthma (SA) and non-severe asthma (NSA). Additionally, we investigated the inflammatory effects of NETs on human airway epithelial cells (AECs) and peripheral blood eosinophils (PBEs). METHODS Peripheral… CONTINUE READING
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