Neutrophil-associated inflammatory responses in rats are inhibited by phenylarsine oxide.

@article{Roussin1997NeutrophilassociatedIR,
  title={Neutrophil-associated inflammatory responses in rats are inhibited by phenylarsine oxide.},
  author={Anne Roussin and V Le Cabec and Michel Lonchampt and J De Nada{\"i} and Emmanuel Canet and Isabelle Maridonneau-Parini},
  journal={European journal of pharmacology},
  year={1997},
  volume={322 1},
  pages={91-6}
}
NADPH oxidase is a phagocyte-specific enzyme which produces O2- and so initiates a cascade of reactive oxygen species formation. Inflammatory diseases involve overproduction of reactive oxygen species which induce tissue damage. Phenylarsine oxide has been described previously as a complete and direct inhibitor of NADPH oxidase in vitro that acts by covalently binding to vicinal thiol groups of a membrane-associated component of the enzyme. In the present work, the potential anti-inflammatory… CONTINUE READING