Neutrophil apoptosis during the development and resolution of oleic acid-induced acute lung injury in the rat.

@article{Hussain1998NeutrophilAD,
  title={Neutrophil apoptosis during the development and resolution of oleic acid-induced acute lung injury in the rat.},
  author={Naveed Hussain and Fayin Wu and Lilly Zhu and Roger Steven Thrall and Mitchell J. Kresch},
  journal={American journal of respiratory cell and molecular biology},
  year={1998},
  volume={19 6},
  pages={
          867-74
        }
}
The oleic acid (OA) model of acute lung injury in rats is characterized by a massive and rapid influx of polymorphonuclear neutrophils (PMN) within 1 h, with a peak inflammatory response at 4 h and resolution by 72 h. We hypothesized that PMN apoptosis is involved in the resolution of OA-induced acute lung injury. To test this hypothesis, healthy adult Fischer 344 rats were given 30 microl OA in 0.1% bovine serum albumin (BSA) intravenously; controls were given BSA alone and killed at 1, 4, 24… CONTINUE READING

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