Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.

  title={Neutrophil antimicrobial proteins enhance Shigella flexneri adhesion and invasion.},
  author={Bj{\"o}rn Eilers and Anne Mayer-Scholl and Travis W. Walker and Christoph M Tang and Yvette Weinrauch and Arturo Zychlinsky},
  journal={Cellular microbiology},
  volume={12 8},
Shigella flexneri is an enteric pathogen that causes massive inflammation and destruction of the human intestinal epithelium. Neutrophils are the first cells of the innate immune system recruited to the site of infection. These cells can attack microbes by phagocytosis, Neutrophil Extracellular Trap (NET) formation and degranulation. Here, we investigated how neutrophil degranulation affects virulence and show that exposure of Shigella to granular proteins enhances infection of epithelial cells… CONTINUE READING


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