Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin.

@article{Jann2009NeutrophilAD,
  title={Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin.},
  author={Naja J. Jann and Mathias Schmaler and Sascha A. Kristian and Katherine A. Radek and Richard L Gallo and Victor Nizet and Andreas Peschel and R{\'e}gine Landmann},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={86 5},
  pages={1159-69}
}
Neutrophils kill invading pathogens by AMPs, including cathelicidins, ROS, and NETs. The human pathogen Staphylococcus aureus exhibits enhanced resistance to neutrophil AMPs, including the murine cathelicidin CRAMP, in part, as a result of alanylation of teichoic acids by the dlt operon. In this study, we took advantage of the hypersusceptible phenotype of S. aureus DeltadltA against cationic AMPs to study the impact of the murine cathelicidin CRAMP on staphylococcal killing and to identify its… CONTINUE READING