Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation.

@article{Page2013NeutrophilAP,
  title={Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation.},
  author={Clive P Page and Simon C Pitchford},
  journal={International immunopharmacology},
  year={2013},
  volume={17 4},
  pages={1176-84}
}
The manifestation of platelet 'satallitism' around neutrophils in whole blood is a long acknowledged phenomenon [1]. Circulating platelet-neutrophil complexes (PNC) occur in a diverse range of inflammatory disorders and infections that affect numerous organs of the body. Animal models have revealed that the formation of PNC is required for the recruitment of neutrophils to inflamed tissue, since platelets 'prime' neutrophils for efficient adhesion to vascular endothelium via the up-regulation… CONTINUE READING