Neutrophil ageing and immunesenescence.

  title={Neutrophil ageing and immunesenescence.},
  author={Janet M. Lord and Suzanne K. Butcher and V Killampali and David Lascelles and Mike Salmon},
  journal={Mechanisms of ageing and development},
  volume={122 14},
As humans age, their morbidity and mortality from infection increases, their response to vaccination declines and they have an increased incidence of inflammatory diseases and cancer. The reasons for these effects are clearly complex, but reduced efficiency of the innate and adaptive immune system is likely to be important in the pathology of old age. Age-related changes in the adaptive immune system are well-documented and include alterations in T cell phenotype and effector functions and a… CONTINUE READING

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