Neutrophil adhesion to E‐selectin under shear promotes the redistribution and co‐clustering of ADAM17 and its proteolytic substrate L‐selectin

@article{Schaff2008NeutrophilAT,
  title={Neutrophil adhesion to E‐selectin under shear promotes the redistribution and co‐clustering of ADAM17 and its proteolytic substrate L‐selectin},
  author={Ulrich Y Schaff and Polly E. Mattila and Scott I. Simon and Bruce Walcheck},
  journal={Journal of Leukocyte Biology},
  year={2008},
  volume={83}
}
E‐selectin is expressed by the vascular endothelium and binds flowing neutrophils in the blood to facilitate their recruitment into the underlying tissue at sites of inflammation. L‐selectin on neutrophils is engaged by E‐selectin and undergoes rapid clustering and then coalescence in the trailing edge of polarizing cells. These processes are believed to increase the valency and capacity of L‐selectin to signal CD18 integrin activity. Neutrophils, upon exiting the microvasculature, down… 

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