Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl‐1

  title={Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl‐1},
  author={Lisa Crossley},
  journal={Journal of Leukocyte Biology},
  • L. Crossley
  • Published 1 October 2003
  • Biology
  • Journal of Leukocyte Biology
Activation signals from bacterial stimuli set into motion a series of events that alter the abbreviated lifespan of neutrophils. These studies show that the bacterial chemoattractant, formyl‐Met‐Leu‐Phe (fMLP), promotes the phosphorylation/inactivation of the FOXO subfamily of forkhead transcription factors (FKHR, FKHR‐L1, and AFX) through the phosphatidylinositol‐3‐kinase/Akt (protein kinase B) and the RAS mitogen‐activated protein kinase pathways. Furthermore, fMLP stimulation causes the… 
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