Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury.

@article{Hiroi2013NeutrophilTC,
  title={Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury.},
  author={Toshihito Hiroi and Teruaki Wajima and Takaharu Negoro and Masakazu Ishii and Yasuko Nakano and Yuji Kiuchi and Yasuo Mori and Shunichi Shimizu},
  journal={Cardiovascular research},
  year={2013},
  volume={97 2},
  pages={271-81}
}
AIMS Transient receptor potential melastatin 2 (TRPM2) highly expressed in immunocytes is a Ca(2+)-permeable non-selective cation channel activated by oxidative stress. Myocardial ischaemia/reperfusion (I/R) injury is characterized by acute inflammation associated with the augmentation of oxidative stress. We hypothesized that TRPM2 is implicated in the exacerbation of myocardial I/R injury. METHODS AND RESULTS Wild-type (Trpm2(+/+)) and Trpm2 knockout (Trpm2(-/-)) mice were subjected to… CONTINUE READING