Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?

@article{Gupta2007NeutrophilNA,
  title={Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?},
  author={Anurag Kumar Gupta and Paul Hasler and Wolfgang Holzgreve and Sinuhe Hahn},
  journal={Seminars in Immunopathology},
  year={2007},
  volume={29},
  pages={163-167}
}
Recent studies have suggested that the innate immune system is involved in the pathogenesis of preeclampsia. Its pathogenesis involves neutrophil activation and increased levels of cell-free DNA in the maternal plasma. Activation of neutrophils has recently been shown to induce DNA containing neutrophil extracellular traps (NETs) which trap and kill bacteria. Massive NETs induction by the placentally derived factors (IL-8 and placental micro-debris) and their increased presence in preeclamptic… Expand
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