Neutrophil Gelatinase B and Chemokines in Leukocytosis and Stem Cell Mobilization

@article{Starckx2002NeutrophilGB,
  title={Neutrophil Gelatinase B and Chemokines in Leukocytosis and Stem Cell Mobilization},
  author={Sofie Starckx and Philippe E. Van den Steen and Anja Wuyts and Jo Van Damme and Ghislain Opdenakker},
  journal={Leukemia \& Lymphoma},
  year={2002},
  volume={43},
  pages={233 - 241}
}
Leukocytosis is a physiopathological mechanism primarily to combat infections, whereas stem cell mobilization is induced for therapeutical purposes. Both processes are dependent on the balance between leukocyte and stem cell retention and mobilization. The retention is mediated by the specific architecture of the bone marrow, adhesion molecules and the production of chemokines in the bone marrow, which attract escaped immature cells to the marrow. Mobilization is the effect of the action of… 
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47 Citations
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Methods Citations
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47 Citations

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Citation Type

Release of matrix metalloproteinase-8 during physiological trafficking and induced mobilization of human hematopoietic stem cells.
TLDR
Evidence is provided that the collagenase MMP-8 can be directly involved in hematopoietic stem cell mobilization and trafficking and in functional assays, adhesion of HSPC to osteoblasts as an essential component of the endosteal stem cell niche is negatively influenced by M MP-8.
Hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor and erythropoietin in the absence of matrix metalloproteinase-9.
The use of mobilized hematopoietic progenitor cells (HPC) has largely replaced the use of bone marrow HPC for autologous and allogeneic transplantation; however, the mechanisms of HPC mobilization…
Regulation of neutrophil homeostasis
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Recent studies have begun to elucidate both the pathways linking neutrophil clearance to granulocyte colony-stimulating factor expression and the mechanisms by which the factor induces neutrophils release from the bone marrow.
Activation of matrix metalloproteinase-9 is associated with mobilization of bone marrow-derived cells after coronary stent implantation.
Citrullination of CXCL8 increases this chemokine’s ability to mobilize neutrophils into the blood circulation
TLDR
Citrullination of CXCL8 enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation and prolonged presentation to the bone marrow.
Reduced expression of inducible gelatinase B/matrix metalloproteinase-9 in monocytes from patients with myelodysplastic syndrome: Correlation of inducible levels with the percentage of cytogenetically marked cells and with marrow cellularity.
TLDR
It is concluded that monocytes can express MMP-9 in response to stromal factors and that this response may be significantly decreased in MDS-derived monocytes.
Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis
TLDR
The kinetics of neutrophil ontogenesis in homeostatic conditions and during emergency myelopoiesis are discussed and an overview of the different molecular players involved in this regulation is provided.
Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.
TLDR
Steady-state neutrophil homeostasis is G-CSF–dependent and regulated through pattern-recognition receptors, thereby directly linking TLR-triggering to granulopoiesis.
Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver.
Recombinant mouse granulocyte chemotactic protein-2: production in bacteria, characterization, and systemic effects on leukocytes.
  • S. Starckx, A. Wuyts, G. Opdenakker
  • Biology
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2002
TLDR
The data reinforce the idea that chemokines, including GCP-2, influence the homeostasis of circulating leukocyte numbers, as well as the systemic effects on neutrophilia and lymphopenia.
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