Neutrophil Extracellular Traps Kill Bacteria

@article{Brinkmann2004NeutrophilET,
  title={Neutrophil Extracellular Traps Kill Bacteria},
  author={Volker Brinkmann and Ulrike Reichard and Christian Goosmann and Beatrix Fauler and Yvonne Uhlemann and David S. Weiss and Yvette Weinrauch and Arturo Zychlinsky},
  journal={Science},
  year={2004},
  volume={303},
  pages={1532 - 1535}
}
Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs… Expand
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