Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis.

@article{Merza2015NeutrophilET,
  title={Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis.},
  author={Mohammed Merza and Hannes Hartman and Milladur Rahman and Rundk Hwaiz and Enming Zhang and Erik Renstr{\"o}m and Lingtao Luo and Matthias M{\"o}rgelin and Sara R{\'e}gner and Henrik Thorlacius},
  journal={Gastroenterology},
  year={2015},
  volume={149 7},
  pages={1920-1931.e8}
}
BACKGROUND & AIMS Neutrophils are involved in the development of acute pancreatitis (AP), but it is not clear how neutrophil-induced tissue damage is regulated. In addition to secreting antimicrobial compounds, activated neutrophils eliminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like structures called neutrophil extracellular traps (NETs). However, NETs have been reported to contribute to organ dysfunction in patients with infectious diseases… CONTINUE READING