Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

@inproceedings{Mitroulis2011NeutrophilET,
  title={Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout},
  author={Ioannis Mitroulis and Konstantinos Kambas and Akrivi Chrysanthopoulou and Panagiotis Skendros and Eirini Apostolidou and Ioannis Kourtzelis and Georgios Drosos and Dimitrios T. Boumpas and Konstantinos Ritis},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β). Since neutrophils play a major role in gout we sought to determine whether their activation may involve the formation of proinflammatory neutrophil extracellular traps (NETs) in relation to autophagy and IL-1β. METHODOLOGY/PRINCIPAL FINDINGS Synovial fluid neutrophils from six… CONTINUE READING