Neutrophil-Derived Hydroxyl Radicals Mediate Interleukin-8-Induced Increases in Tetragastrin-Stimulated Acid Secretion in Rats

@article{Yakabi2003NeutrophilDerivedHR,
  title={Neutrophil-Derived Hydroxyl Radicals Mediate Interleukin-8-Induced Increases in Tetragastrin-Stimulated Acid Secretion in Rats},
  author={Koji Yakabi and Harumi Mimura and Hitoshi Iwabuchi and Shoki Ro and Hideo Kamiichi and Seiichi Miura and Takashi Nakamura},
  journal={Digestive Diseases and Sciences},
  year={2003},
  volume={48},
  pages={1081-1087}
}
Until recently, the secretion of gastric acid, which plays an important role in the pathogenesis of peptic ulcer, was thought to be controlled by diet, the autonomic nerves and gut hormones. However, peptic ulcer is now known to be caused by the infection with Helicobacter pylori (H. pylori), so it is possible that inflammation modifies the secretion of gastric acid. We used gastric-lumen-perfused rats to first examine the effect of interleukin-8 (IL-8) on acid secretion and then the… CONTINUE READING

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