Neutrophil CD64: a diagnostic marker for infection and sepsis.

  title={Neutrophil CD64: a diagnostic marker for infection and sepsis.},
  author={Johannes J. M. L. Hoffmann},
  journal={Clinical chemistry and laboratory medicine},
  volume={47 8},
Neutrophilic granulocytes express Fcgamma receptor (FcgammaR) [cluster of differentiation 64 (CD64) antigen] only when they are activated. Neutrophil CD64, demonstrated using flow cytometry, can be used as a diagnostic marker of infection and sepsis. Neutrophil CD64 is superior to C-reactive protein and hematological determinations for detecting systemic infection or sepsis, since it combines high sensitivity (90% or more) with high specificity (90%-100%) in both adults and children. In… CONTINUE READING

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