Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury.


RATIONALE TRPM2 (transient receptor potential melastatin-2) expressed in endothelial cells (ECs) is a cation channel mediating Ca2+ entry in response to intracellular generation of adenosine diphosphoribose-the TRPM2 ligand. OBJECTIVE Because polymorphonuclear neutrophils (PMN) interaction with ECs generates reactive oxygen species, we addressed the… (More)
DOI: 10.1161/CIRCRESAHA.117.311747


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