Neutropenia and anaemia associated with T-cell large granular lymphocyte leukaemia responds to fludarabine with minimal toxicity.

@article{Sternberg2003NeutropeniaAA,
  title={Neutropenia and anaemia associated with T-cell large granular lymphocyte leukaemia responds to fludarabine with minimal toxicity.},
  author={Alexander J Sternberg and Helen Jane Eagleton and N. Padmanabha Pillai and Kevin Leyden and Susan B Turner and Danita M. Pearson and Timothy James Littlewood and Chris Hatton},
  journal={British journal of haematology},
  year={2003},
  volume={120 4},
  pages={699-701}
}
T-cell large granular lymphocyte leukaemia (T-LGL) is a clonal disorder of T cells associated with neutropenia and anaemia. The clinical consequences are recurrent infections and transfusion dependence. The optimum treatment for severely affected patients remains to be defined. Current therapies require long-term administration to maintain an effect. We report the reversal of severe neutropenia and/or anaemia in four patients treated with fludarabine which has been maintained since stopping… CONTINUE READING
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