Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis.

@article{Robertson2003NeutralizingTN,
  title={Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis.},
  author={Morag Robertson and Janet Liversidge and John V. Forrester and Andrew D Dick},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 7},
  pages={
          3034-41
        }
}
PURPOSE During experimental autoimmune uveoretinitis (EAU), infiltrating macrophages become activated to express nitric oxide synthase (NOS)-2 and generate nitric oxide (NO). The current study was designed to determine whether neutralizing TNF activity with a soluble fusion protein of TNFp55 receptor (sTNFr-IgG) inhibits macrophage activation, thereby contributing to reduced tissue damage observed with such treatment. METHODS EAU was induced in Lewis rats by active immunization with soluble… CONTINUE READING

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