Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-alpha-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria.

@article{Schofield1993NeutralizingMA,
  title={Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-alpha-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria.},
  author={Louis Schofield and Livia Vivas and F Kevin Hackett and Peter Gerold and Ralph T. Schwarz and Souvenir D. Tachado},
  journal={Annals of tropical medicine and parasitology},
  year={1993},
  volume={87 6},
  pages={617-26}
}
Tumour necrosis factor-alpha (TNF-alpha) is an endogenous mediator of shock and inflammation. Many of the life-threatening and severe pathologies associated with complicated and cerebral malaria are thought to result from the overproduction of this cytokine in response to agents of parasite origin. The identification and characterization of these agents may therefore provide the molecular basis for a detailed understanding of the disease process. Recently it has been shown that… CONTINUE READING

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