Neutralizing monoclonal antibodies that distinguish three antigenic sites on human cytomegalovirus glycoprotein H have conformationally distinct binding sites.

@article{Simpson1993NeutralizingMA,
  title={Neutralizing monoclonal antibodies that distinguish three antigenic sites on human cytomegalovirus glycoprotein H have conformationally distinct binding sites.},
  author={Joycelyn Simpson and Jennifer C. Chow and Jannine M Baker and Neboj{\vs}a Avdalovi{\'c} and Shishan Yuan and Dennis Au and Man Sung Co and M{\^o}nica Lopez Vasquez and William J Britt and Kathleen L. Coelingh},
  journal={Journal of virology},
  year={1993},
  volume={67 1},
  pages={489-96}
}
Seven neutralizing murine monoclonal antibodies specific for the glycoprotein H of human cytomegalovirus were produced and used to construct a topological map of two nonoverlapping antigenic sites that are bridged by a third antigenic site. Neutralization assays with 15 laboratory or clinical human cytomegalovirus strains indicated that the monoclonal antibodies recognize three antigenically variable and three conserved epitopes within the three antigenic sites. The variable-domain genes… CONTINUE READING

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