Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen.

@article{KellyCirino2009NeutralizingMA,
  title={Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen.},
  author={Cassandra D Kelly-Cirino and Nicholas J Mantis},
  journal={Infection and immunity},
  year={2009},
  volume={77 11},
  pages={4859-67}
}
The anthrax protective antigen (PA) is the receptor-binding subunit common to lethal toxin (LT) and edema toxin (ET), which are responsible for the high mortality rates associated with inhalational Bacillus anthracis infection. Although recombinant PA (rPA) is likely to be an important constituent of any future anthrax vaccine, evaluation of the efficacies of the various candidate rPA vaccines is currently difficult, because the specific B-cell epitopes involved in toxin neutralization have not… CONTINUE READING
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