Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.

@article{Ardestani2011NeutralizingI,
  title={Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.},
  author={Amin Ardestani and Nadine S. Sauter and Federico Paroni and Gitanjali Dharmadhikari and Jae Hyoung Cho and R. Miguel Lupi and Piero Marchetti and Jos{\'e} Oberholzer and Julie Kerr Conte and Kathrin Maedler},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 19},
  pages={17144-55}
}
The transcription factor PDX1 plays a critical role during β-cell development and in glucose-induced insulin gene transcription in adult β-cells. Acute glucose exposure leads to translocalization of PDX1 to the nucleoplasm, whereas under conditions of oxidative stress, PDX1 shuttles from the nucleus to the cytosol. Here we show that cytosolic PDX1 expression correlated with β-cell failure in diabetes. In isolated islets from patients with type 2 diabetes and from diabetic mice, we found… CONTINUE READING
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