Neutralizing epitopes of influenza virus hemagglutinin: target for the development of a universal vaccine against H5N1 lineages.

@article{Prabakaran2010NeutralizingEO,
  title={Neutralizing epitopes of influenza virus hemagglutinin: target for the development of a universal vaccine against H5N1 lineages.},
  author={Mookkan Prabakaran and Fang He and Tao Meng and Selvaraj Madhan and Tan Yunrui and Qiang Jia and Jimmy Kwang},
  journal={Journal of virology},
  year={2010},
  volume={84 22},
  pages={11822-30}
}
The nature of influenza virus to randomly mutate and evolve into new types with diverse antigenic determinants is an important challenge in the control of influenza infection. Particularly, variations within the amino acid sequences of major neutralizing epitopes of influenza virus hemagglutinin (HA) hindered the development of universal vaccines against H5N1 lineages. Based on distribution analyses of the identified major neutralizing epitopes of hemagglutinin, we selected three vaccine… CONTINUE READING

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