Neutralizing endogenous VEGF following traumatic spinal cord injury modulates microvascular plasticity but not tissue sparing or functional recovery.

@article{Benton2009NeutralizingEV,
  title={Neutralizing endogenous VEGF following traumatic spinal cord injury modulates microvascular plasticity but not tissue sparing or functional recovery.},
  author={Richard L. Benton and Melissa A. Maddie and Mark J Gruenthal and Theo Hagg and Scott R Whittemore},
  journal={Current neurovascular research},
  year={2009},
  volume={6 2},
  pages={
          124-31
        }
}
Acute loss of spinal cord vascularity followed by an endogenous adaptive angiogenic response with concomitant microvascular dysfunction is a hallmark of traumatic spinal cord injury (SCI). Recently, the potent vasoactive factor vascular endothelial growth factor (VEGF) has received much attention as a putative therapeutic for the treatment of various neurodegenerative disorders, including SCI. Exogenous VEGF exerts both protective and destabilizing effects on microvascular elements and tissue… CONTINUE READING