Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection.

@article{Pilgrim1997NeutralizingAR,
  title={Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection.},
  author={A K Pilgrim and Giuseppe Pantaleo and Oren Cohen and Louis M. Fink and J Y Zhou and Jin Tao Zhou and Dani P. Bolognesi and Anthony S. Fauci and David C. Montefiori},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={176 4},
  pages={924-32}
}
The role of neutralizing antibodies in human immunodeficiency virus type 1 (HIV-1) infection is poorly understood and was assessed by evaluating responses at different stages of infection. Undiluted sera from long-term nonprogressors (LTNP) had broad neutralizing antibodies against heterologous primary isolates and were more likely to neutralize the contemporaneous autologous isolate than were sera from short-term nonprogressors and progressors. In primary infection, envelope-specific IgG was… CONTINUE READING