Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes.

Abstract

Dendritic cells (DCs) support only low levels of HIV-1 replication, but have been shown to transfer infectious viral particles highly efficiently to neighboring permissive CD4 T lymphocytes. This mode of cell-to-cell HIV-1 spread may be a predominant mode of infection and dissemination. In the present study, we analyzed the kinetics of fusion, replication… (More)
DOI: 10.1182/blood-2012-03-418913

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@article{Su2012NeutralizingAI, title={Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes.}, author={Bin Su and Ke Xu and Alexandre Lederle and Maryse Peressin and Marina Elizabeth Biedma and G{\'e}raldine Laumond and Sylvie Schmidt and Thomas Decoville and Aliz{\'e} Proust and M{\'e}lanie Lambotin and Vincent Holl and Christiane Moog}, journal={Blood}, year={2012}, volume={120 18}, pages={3708-17} }