Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes.

@article{Matyas2009NeutralizingAI,
  title={Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes.},
  author={Gary R Matyas and Lindsay Wieczorek and Zolt{\'a}n Beck and Christina Ochsenbauer-Jambor and John C Kappes and Nelson L Michael and Victoria Polonis and Carl R. Alving},
  journal={AIDS},
  year={2009},
  volume={23 16},
  pages={2069-77}
}
OBJECTIVES There is a need to develop HIV-1 vaccine formulations that incorporate inexpensive antigens and clinically acceptable potent adjuvants for inducing neutralizing antibodies. The purpose of this initial vaccine study was to produce peptide- and lipid-induced murine mAbs that replicate the characteristics of the 2F5 and/or 4E10 human antibodies in binding both to the membrane proximal external region (MPER) of glycoprotein 41 and the adjacent lipid bilayer for neutralizing HIV-1… CONTINUE READING

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