Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype.

@article{Girard2017NeutralizingAT,
  title={Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype.},
  author={Alexandre Girard and Katija Jelicic and Don Van Ryk and Nicolas Rochereau and Claudia Cicala and James A. Arthos and Blandine Noailly and Christian Genin and Bernard Verrier and St{\'e}phanie Laurant and Diane Razanajaoana-Doll and Jean-Jacques Pin and St{\'e}phane Paul},
  journal={Journal of acquired immune deficiency syndromes},
  year={2017},
  volume={75 1},
  pages={118-127}
}
The homing of lymphocytes to the mucosa is mainly controlled by α4β7 integrin, and it is amplified during gut chronic inflammation, as occurs with HIV and/or inflammatory bowel diseases. We designed and applied an improved immunization strategy based on an innovative selection process to isolate new α4β7 lymphocyte-specific monoclonal antibodies that are… CONTINUE READING